I did some digging, and from what Ive read it sounds like just one report would be considered anecdotal and would not be considered evidence that Seresto could cause seizures, but if there are 2 or more reports then the company might be obliged by the EPA to add a potential seizure warning to its label or possibly to do more clinical safety research. Simparica TRIO. As with everything else, monitor your dog for symptoms. for, I think its brown ticks. Thank you for your article. I do not know if my auss is a carrier for the mdr1 gene, and I told the vet about this and they double checked and said that the drugs in simparica trio should be fine for her. (Bacon) 3.8 (6,612) $2691 ($0.19/Count) $24.22 with Subscribe & Save discount. No treatment-related clinical signs were observed. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. If youre hoping for a quick, easy skim and just want to know which pest protections are considered safe, Ill list those first under each heading, followed by the use with caution category, and finally the not safe options. Some swear by food grade DE (diatomaceous earth) as a natural dewormer of roundworms, hookworms, whipworms, and even tapeworms. I appreciate the research in this thank you! Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. Giardia can be passed to and cause diarrhea in humans. Frontline Plus is milder than Frontline Gold, which I wouldnt recommend for the same reason that I dont like recommending Advantix theyre too strong and have a tendency to cause skin reactions. Get new post updates in monthly email newsletters. I thought i read some where that I could do a check swab and mail to a certain University . Im trying to find out if this is safe for her. Simparica comes as flavored, chewable tablets and is available in a variety of sizes: 5, 10, 20, 40, 80, and 120 mg. 6. ( I had to get a different vet for my pup because my current vet couldnt get him in to start his vacines for 2.5 months. Thank you again for all your help : ). Simparica Trio works against the same ticks as Nexgard and also protects your dog from heartworms, hookworms, and roundworms. GSD is an abbreviation for German Shepherd Dog , Thankyou so much for your articleso much great infoI have a 7 month mini Aussieon Symparticabut not feeling good about itshe hasnt been tested for MRD1 but I know I have to change it upthankyou again , Youre very welcome, and good luck with your pup! . Happy to help! Fortunately, there is a DNA test that will let you know whether your dog has this mutation. Study free flashcards about heartworm extra note created by Dkamplain to improve your grades. Demonstrated 98.9% effectiveness against existing tick infestations in 48 hours . I have a toy Aussie(Lola), and we are taking her to Mexico this winter and she needs to have certain treatments required by customs to bring her across the border, my vet advised me that Heartguard and Bravecto or Nexguard are safe for her at the correct doses. The Whole Dog Journal notes that Ivermectin has the most potential for toxicity.. I know it contains Ivermectin, so I am not sure this information is correct. I had started my GSD on Revolution, but really always liked Frontline better and since that seems to cover more ticks and still protect us from unwanted mites I probably will lean toward that. We took her to a vet who is very experienced with collies (she helps with a rescue) and has assured me that Simpirica Trio is safe. Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. But of course, do talk to your vet and see what they know. Thanks for your efforts to help! Could you send the link to that article you found? Im happy to hear you found it helpful! According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. Simparica Trio treats and protects against harmful parasites. I did write this article a couple of years ago; but I have updated it several times since most recently after information came out about some fatal reactions to Seresto collars. We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. Prevents: Heartworm, Fleas, Intestinal worms (except tapeworm) Comes as: a meaty chew given once every month (afoxolaner & milbemycin) Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. Be prepared to answer questions about whether your dog had a previous history with seizures, has any drug sensitivities, if anything else could possibly have triggered a seizure, and if she has had any seizures since the collar was removed. I think this is a couple years old. Oh no! The Whole Dog Journal points out that oral flea-control medications have been proven to be more effective than topical pesticides in both killing fleas and helping to control a household infestation more quickly. While this is true, the benefit of topical treatments is in their general safety. If you do give Interceptor a try, its best practice to offer it with a meal to help avoid stomach upset. They both have tolerated Bravecto very well.no noticeable side effects. Simparica Trio is FDA-Approved and can be purchased with a prescription. 1x 10mg tablet for 5.6 to 11 pounds. Except for the warning about Cats who have close contact with collies, my impression was that you thought K 9 Advantix was safe and effective for Collies. A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. My Collie is double MDR1 mutant. I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. Simparica Trio is an all-in-one monthly chewable treatment for dogs. I would actually place it in the caution category, since if a dog who had an active heartworm infection was given diethylcarbamazine (Dimmitrols main ingredient) it could suffer severe side effects and even die. I know youre very particular about the genetic health of your Collies, and I admire your breeding program. Simparica Trio 11.1-22 lbs. The flavored, chewable tablets were consumed . Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. . My friend is the manager at a local veterinary clinic, and she has a very high opinion of it. I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. Any thoughts on either of these? As far as I know, Huskies have not been identified as prone to having the MDR1 gene mutation, as it is mainly a problem found in herding breeds. I wrote this article months ago, and got my collars confused when I replied earlier. However, Ive had the best results with a medicated ear mite treatment prescribed by my veterinarian. Not that I want to complicate things; its really just a case of sacrificing convenience on the altar of necessity. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. I have an Aussie mix and desperately needed some info on this. Hope this helps! Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. Later, the vet had the experience of this happening to other cats and one of his own. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. I just picked out a beautiful tri color rough collie this morning! One observation: You mention that Credelio has fewer reported seizures (6 in as many months) than other drugs in the isoxazaline class. Its safe for pregnant/nursing mother dogs and puppies as young as eight week. $153.89. She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). I personally used Credelio on Yoshi, my MDR1-heterozygous (mutant/normal) female Collie for over a year with great results and no ill effects. Review this. I know Simparica is more convenient since it means giving one monthly preventive instead of two, but the trade-off with the combo meds is that theyre usually stronger. Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . Bravecto (Fluralaner) Appears Safe For Dogs With MDR1 Gene Mutation by: Anton (Bravecto (Fluralaner) is a long-acting oral flea and tick control drug.) Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). How to use Simparica Trio. Submit a story, ask a question, or just say hi; Emily would love to hear from you. Hello! If Seresto seems to be negatively affecting your dog, remove it and bathe the dog (paying particular attention to the neck area) with a gentle shampoo and multiple rinses. 4.11 Withdrawal period(s) LIST OF DRUGS THAT CAUSE SENSITIVITY TO DOGS WITH MDR1 MUTATION. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). I was unaware of MDR1 Mutation drug reactions at the time. We have an 11 year old tricolor rough coat collie. The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. - It is easy to administer, with no need for pre-treatment or fasting. As one holistic veterinarian explains: The Vectra 3D can have side effects which include extreme restlessness and jitteriness, described as anxiety or manic behavior. My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. Based on your recommendations, I will not use Vectra. I have never even heard of the latter and do not believe they exist in Canada. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. Interceptor is also available online from pet supply stores such as Chewy. Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. Kills 5 types of ticks. There weren't as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. Simparica Trio has the same main ingredient as . Please log in again. What an awesome article. Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! Safe in avermectin-sensitive collies and dogs with the MDR1 gene; Interceptor was also recommended by my entire local Collie Club, including Pati Merrill, the retired former president of the Collie Health Foundation. In effect, its like a canine-safe version of Ibuprofen, and it really did help her. We love her. I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. Use ProHeart 6 in dogs 6 months of age or older and ProHeart 12 in dogs 12 months of age or older. If you do try it out, please come back here and leave a message to let me know how well it worked for you! Simparica Trio proven to block the pathogen that causes Lyme disease by killing deer ticks . Thank you for your article. We are waiting for the results from her test for the MDR1 gene. Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. I just quote the ones who are knowledgeable about MDR1. Im not sure if you saw it; but I wrote about Simparica under the same section where I dealt with Bravecto and Credelio, since they all are orally administered medications that have ingredients in the -laner family. Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. Please keep me updated if you think of it! . SIMPARICA TRIO killed fleas before they could lay eggs for 35 days. Trish. It is approved for use on puppies at least 3 pounds in weight and 7 weeks of age, cats, and even ferrets. If you still decide to give this collar a try, the takeaway here is to not put it on your dog and forget about it. Nexgard and Simparica. Rev. Simparica Trio reduced live flea counts, as well as clinical signs of FAD, by 99.0% at day 30 and by 99.7% at day 60. I gave her Simparica 5 weeks ago for the first time. From the standpoint of MDR1 dogs, it is safe. But it doesnt hurt mammals. The tail curling and pacing lasted over a week. Id like to thank you so very much for this in depth article. I found it extremely helpful & educational. Frontline Gold and Frontline Shield. And safe travels to you and Lola in the future. Safety. If youre looking for something that will repel parasites, a product such as K9 Advantix II may make a good alternative. 5 A dog's reaction to flea bites may vary from sores and inflammation to hair loss. Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. Hi! Safety has not been evaluated in pregnant, breeding or lactating dogs. Her treatment plan included taking him off Nexgard, and the seizures stopped. Matching game, word search puzzle, and hangman also available. Happy to help! Roxie has never been tested, but she is Dashs niece so probably also mutant/normal if I were to guess. Nothing could be done for them. I have 7 collies and I am reluctant to put them on anything thats not natural , we did get a kitten and found a flea so looking for something to treat all as a precautionary for a month as we are in winter season in Northern Ontario Canada. I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. For dogs who have a case of mange or ear mites, the treatment can involve topical applications of compounds containing (you guessed it) Ivermectin. K9 Advantix II Flea, Tick and Mosquito Prevention for Dogs, 6 Doses. Emily is an avid writer, blogger, and Collie lover who collects and posts stories about Collies from around the world. What do you think about Frontline Gold? THANK YOU, THANK YOU, THANK YOU! Capstar specifically targets adult fleas, so it is best paired with a product like Sentinel. Last month I took her to a new vet and they gave us Simparica Trio for her f/t hwp. Negative reactions such as vomiting, diarrhea, and tremors were only observed at supratherapeutic (higher than recommended) doses. FREE delivery Tue, Mar 7. I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. I have a unique situation. Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. First, I want to thank you for the time and effort that went into writing this article. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. Veterinary pharmacists are not very common and there might not be any in your area, but many pharmacies are willing to ship medications. As the agency explained: Although FDA scientists carefully evaluate an animal drug prior to approval, there is the potential for new information to emerge after marketing, when the product is used in a much larger population. (New drugs continue to be highly monitored for the first three years following their release.). Those are both still very effective products, but have fewer horrror stories of terrible skin reactions. Waxman and Brooks both recommend it. This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. She had a severe reaction with diarrhea, drooling, depression etc. They were extremely helpful people. The Vet is too expensive! Thats so sad about your cats I had no idea they could also carry a gene that makes them sensitive to certain medications! Where can I get them tested for MDR1 resistance. Thank you for all your research and article!! They said Frontline Plus doesnt really work anymore like it used too. While this study conducted on twenty MDR1-affected Collies did not reveal any adverse reactions when the dogs were given low doses of Milbemycin Oxime combined with Spinosad, the Washington State University of Veterinary Medicine does advise that some of the combination flea+heartworm preventive products (those containing spinosad) should be used cautiously in dogs that are MDR1 mutant/normal because of a risk of serious drug-drug interactions.. I would appreciate your comments on Advocate. Thank you! Is Simparica Trio safe for dogs with MDR1? When reading about Seresto, their website said it doesnt work well on dogs with heavy coats, ie. He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. We actually live in New Hampshire and hike (off-leash) quite frequently. Eliminate fleas before they lay eggs. 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